Heartgard® Plus for Dogs [6 Doses per Box]


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Prescription Medications

Prescription medications and Nutramax branded product purchases require that your pet has a doctor-patient relationship with a veterinarian at Town & Country Vet Clinic in Marietta, GA


What is Heartgard Plus Chewables?

Heartgard Plus Chewables provides protection against heartworms, and treats and controls roundworms and hookworms. These tasty chewables are made with real beef, making them easy to give your dog like a treat. Heartgard Plus Chewables is given monthly and requires a prescription from your veterinarian.


Dogs (6 weeks of age or older and no weight requirement)

  • Effectively prevents heartworms
  • Treats and controls roundworms & hookworms
  • Only given once a month
  • Delicious beef flavor makes them easy to administer
How do Heartgard Plus Chewables work?

Heartgard Plus Chewables contains ivermectin, a broad-spectrum antiparasitic medication used to prevent heartworms. It also contains Pyrantel Pamoate, an anthelminthic, used to prevent roundworms and hookworms.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.

Cautions when giving Heartgard Plus Chewables:

Heartgard Plus Chewables may cause sensitivities in herding dog breeds. Heartgard Plus Chewables should be chewed, not swallowed whole. The chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Make sure that your dog eats the entire dose. It is important to give your dog Heartgard Plus Chewables every month year-round. Do not skip winter months, as your dog may become infected if left unprotected. If you miss than two months of dosage, please consult with your veterinarian as to whether to continue medication.

Brand Name:

Heartgard Plus (Merial), Iverhart Plus (Virbac), Tri-Heart Plus (Intervet)

Generic Name:

Ivermectin, Pyrantel pamoate

Who makes Heartgard Plus Chewables?


What are the active ingredients in Heartgard Plus Chewables ?

Ivermectin, Pyrantel

What should I discuss with my veterinarian before giving Heartgard Plus Chewables to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.

How should Heartgard Plus Chewables be given?

Give Heartgard Plus Chewables exactly as directed by the veterinarian. If you do not understand the directions, ask the pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Heartgard Plus Chewables at room temperature. Do not remove the chewable from its wrapper until ready to give the medicine. Keep this medication away from children and pets. In addition, Heartgard Plus Chewables has shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.

What happens if I miss giving a dose of Heartgard Plus Chewables?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I do if an accidental overdose of Heartgard Plus occurs?

Seek emergency veterinary medical treatment.

What should I avoid while giving Heartgard Plus Chewables to my pet?

Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Heartgard Plus Chewables?

Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and death.

What other drugs will affect Heartgard Plus Chewables?

Do not give Heartgard Plus Chewables to your pet if already taking another heartworm medication.

Additional information

Weight 1 lbs
Dimensions 4 × 1 × 2 in

Under 25 pounds, 26 – 50 pounds, 51 – 100 pounds

How to Use

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only. Do not give to cats.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove chewable from its wrapper until ready to give to pet.

Dogs/Puppies: (6 weeks of age and older)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight


Heartgard Blue Chewables (for Dogs 1-25 lbs):
Active Ingredient
68 mcg
57 mg
Heartgard Green Chewables (for Dogs 26-50 lbs):
Active Ingredient
136 mcg
114 mg
Heartgard Brown Chewables (for Dogs 51-100 lbs):
Active Ingredient
272 mcg
227 mg


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